* Coming from '''Hanover''', follow Autobahn A2 heading towards Berlin, coming from '''Berlin''' head towards Hanover accordingly. At interchange Braunschweig-Nord change to A391 for Braunschweig-Südwest.
* Coming from '''Kassel''' or '''Hildesheim''': Autobahn A7 until interchange Derneburg/Salzgitter, then change to A39 towards Braunschweig. At interchange Braunschweig-Südwest, head for A2/Braunschweig Nord on A391.
* Coming from '''Hanover''', follow Autobahn A2 heading towards Berlin, coming from '''Berlin''' head towards Hanover accordingly. At interchange Braunschweig-Nord change to A391 for Braunschweig-Südwest.
* Coming from '''Kassel''' or '''Hildesheim''': Autobahn A7 until interchange Derneburg/Salzgitter, then change to A39 towards Braunschweig. At interchange Braunschweig-Südwest, head for A2/Braunschweig Nord on A391.